As a direct consequence of the sophisticated arrangement of its intrinsic neurons, the gastrointestinal tract is unique among peripheral organs, in its ability to mediate its own reflexes. Neurons of the enteric nervous system are intimately associated with enteric glial cells. These supporting cells do not resemble Schwann cells, the glial cell found in all other parts of the peripheral nervous system, but share many similarities with astrocytes of the central nervous system. Ablation of enteric glial cells in adult transgenic (...) mice has demonstrated that these cells are essential to maintain the integrity of the small intestine. Acute loss of enteric glial cells induces massive pathological changes with similarities to necrotizing enterocolitis (NEC) and early Crohn's disease. These human conditions share some mechanistic similarities. Identification of enteric glial cell dysfunction/loss as sufficient to induce necrotic/inflammatory bowel disease may be important to understand the pathogenesis of both NEC and Crohn's disease. BioEssays 24:130–140, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This book explores the thought of Jacques Derrida as it relates to the tradition of apophatic thought--negative theology and philosophy--in both Western and Eastern traditions. Following the Introduction by Toby Foshay, two of Derrida's essays on negative theology, Of an Apocalyptic Tone Newly Adopted in Philosophy and How to Avoid Speaking: Denials, are reprinted here. These are followed by essays from a Western perspective by Mark C. Taylor and Michel Despland, and essays from an Eastern perspective by David Loy, (...) a Buddhist, and Harold Coward, a Hindu. In the Conclusion, Jacques Derrida responds to these discussions. (shrink)

Background Institutional Review Boards (IRBs) are federally mandated to include both nonscientific and unaffiliated representatives in their membership. Despite this, there is no guidance or policy on the selection of unaffiliated or non-scientist members and reports indicate a lack of clarity regarding members’ roles. In the present study we sought to explore processes of recruitment, training, and the perceived roles for unaffiliated and non-scientist members of IRBs.Methods We distributed a self-administered REDCap survey of members of the Association for the Accreditation (...) of Human Research Protection Programs familiar with IRB member recruitment. The survey included closed and open-ended questions regarding: the operation of the HRPP/IRB(s), how unaffiliated and non-scientist members are recruited, whether they had faced challenges recruiting for these roles, and training and mentorship offered. The survey also collected information regarding the perceived value and roles of unaffiliated and non-scientist members.Results 76 responses were included in the analysis (38% completion rate). The most common approach for recruitment was referral from current IRB members, with almost half of respondents indicating challenges recruiting unaffiliated members. Over 75% indicated no additional training was provided to unaffiliated or non-scientist members compared to affiliated or scientist members. Most common supports provided were travel/parking expenses and honoraria. Commonly perceived roles were to provide an independent voice from the participant perspective, notably regarding consent processes and materials.Conclusions Respondents indicated challenges in defining unaffiliated and non-scientist members and limited practices toward recruitment and support. Future work should more closely examine the challenges in defining these roles and applying the definitions in practice, as well as strategies that may improve recruitment and retention of unaffiliated and non-scientist members. (shrink)

In the United States of America, the years from 1880 to 1915 were a period of rapid urbanization, combined in some areas with intense industrialization. This paper explores the creation in cities of the new industrial heartland of new institutions of higher learning. The case studies chosen illustrate varying responses to local needs for scientific and technical expertise, and illuminate how new concepts of higher education in the United States helped to shape the emergent connection between science and industry.

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

The deliberative systems approach is a recent innovation within the tradition of deliberative democratic theory. It signals an important shift in focus from the political legitimacy produced within isolated and formal sites of deliberation (e.g., Parliament or deliberative mini-publics), to the legitimacy produced by a number of diverse interconnected sites. In this respect, the deliberative systems (DS) approach is better equipped to identify and address defects arising from the systemic influences of power and coercion. In this article, I examine one (...) of the least explored and least understood defects: the exclusion of non-speaking political actors generated by the uniform privileging of speech in all sites within a system. Using the examples of prefigurative protest, Indigenous refusal to deliberate, and the non-deliberative agency of disabled citizens, I argue that the DS approach allows theorists to better understand forms of domination related to the imposition of speech on those who are either unwilling or unable to speak. (shrink)

Political obligation is concerned with the clash between the individual’s claim to self-governance and the right of the state to claim obedience. It is a central and ancient problem in political philosophy. In this authoritative introduction, Dudley Knowles frames the problem of obligation in terms of the duties citizens have to the state and each other. Drawing on a wide range of key works in political philosophy, from Thomas Hobbes, John Locke, David Hume and G. W. F. Hegel to (...) John Rawls, A. John Simmons, Joseph Raz and Ronald Dworkin, Political Obligation: A Critical Introduction is an ideal starting point for those coming to the topic for the first time, as well as being an original and distinctive contribution to the literature. Knowles distinguishes the philosophical problem of obligation - which types of argument may successfully ground the legitimacy of the state and the duties of citizens - from the political problem of obligation - whether successful arguments apply to the actual citizens of particular states. Against the anarchist and modern skeptics, Knowles claims that a plurality of arguments promise success when carefully formulated and defended, and discusses in turn ancient and modern theories of social contract and consent, fairness and gratitude, utilitarianism, justice and a Samaritan duty of care for others. Against modern communitarians, he defends a distinctive liberalism: ‘the state proposes, the citizen disposes’. (shrink)

It is typically thought that a student deserves—or at least can deserve—a grade in a class. The students who perform well on assessments, who display a high degree of competence, and who complete all of the required work, deserve a good grade. Students who perform poorly on assessments, who fail to understand the course material, and who fail to complete the required work, deserve a bad grade. In this paper, I raise a challenge to this conventional view about grades. In (...) particular, I challenge the idea that grades—understood appropriately—can be objects of desert for class performance. In other words, grades are simply not the kind of thing that can be deserved. The argument is roughly as follows. In general, when some property or quality of ours is measured, where that property or quality is something that makes us deserving of something, the measurement, itself, is not the thing that is or could be deserved. Grades, however, are a measure of student performance, where performance is meant to be the basis on which students deserve their grades. Since they are mere measures of performance, grades are not and could not be deserved on the basis of performance, and so are not possible objects of desert. Rather, they serve as evidence of the desert basis (academic performance, e.g.) that grounds a student’s being deserving of other objects (praise or recognition, e.g.). In short, grades, at best, measure how deserving one is, but grades themselves are not deserved. (shrink)

Blackburn’s dilemma (as commonly understood) is that in explaining truths of the form ‘Necessarily-P’ we have to appeal either to a necessary truth, in which case we don’t seem to make the right kind of progress, or to a contingent truth, in which case we seem to undermine the necessity we were meant to be explaining. This paper advances two claims. First, it is argued that the dilemma is wider in scope than usually supposed. The standard assumption (evident also in (...) Black-burn’s original paper (1993)) is that the dilemma applies to explanations of truths of the form ‘Necessarily-P’. I argue that the real problem identified by Blackburn doesn’t just apply to explanations of truths of this form, but to explanations of necessary truths in general (e.g. truths of logic, mathematics, etc.). In the course of this argument it also transpires that the real problem on the necessity horn is rather different—and rather less susceptible to obvious objections—than it is usually taken to be. It concerns the antinaturalistic core of necessity. Second, it is argued that there is an escape from the antinaturalistic core on the contingency horn. In the footsteps of Wright (1985), the claim is that the contingency horn is tenable for those who believe that the necessary truth in question is analytic, i.e. follows from its meaning. (shrink)

In JAP 9 (1992) Gordon Graham argued that liberals cannot be counted on to support democratic institutions since there are no conceptual or strongly contingent links between democracy and liberal ideals. This paper responds to Graham's challenge by claiming that his model of liberal aristocracy is not liberal in several respects. In particular, the liberal should recognise a right to democratic participation which individuals may plausibly claim as an element in a respectable conception of how to live well. The right (...) to democratic participation is shown to stand alongside other important liberal ideals which may be justified in this fashion, e.g. freedom of religious worship and freedom of association. Furthermore, I argue against those who claim that political participation enacts delusory aspirations that the rights which are promoted and protected within a democratic constitution are necessary for both individual and collective autonomy — and so the liberal should defend them. (shrink)

Hegel is notable for his distinctive contribution to the perennial concerns of political philosophy. The essays in this volume bring together some of the finest interpreters of Hegel writing in English, explore his distinguished heritage and explain its contemporary relevance.

Noam Chomsky claims that we know the grammatical principles of our languages in pretty much the same sense that we know ordinary things about the world (e.g. facts), a view about linguistic knowledge that I term ''cognitivism''. In much recent philosophy of linguistics (including that sympathetic to Chomsky's general approach to language), cognitivism has been rejected in favour of an account of grammatical competence as some or other form of mental mechanism, describable at various levels of abstraction (''non-cognitivism''). I argue (...) for cognitivism and against non-cognitivism. First, I show that the distinction between competence and performance in current linguistics is as clearly made as ever it was, in spite of recent interest in linguistic processing modules. Second, I use these facts about the practice of theoretical linguistics to refute various proposals for a non-cognitivist construal of grammatical competence, and to support cognitivism by reflecting on the inapplicability of a multi-level account of linguistic competence. Cognitivism is then defended against several objections centring around the problems of rational integration and conceptualization of grammatical knowledge. Finally, the conception of competence argued for in relation to linguistics is placed in the larger context of cognitive science research and its implications for philosophy of mind. (shrink)

The position of some environmental ethicists that some non-humans have intrinsic value as a mind-independent property is seriously flawed. This is because human beings lack any evidence for this position and hence are unjustified in holding it. For any possible world that is alleged to have this kind of intrinsic value, it is possible to conceive an observationally identical world that lacks intrinsic value. Hence, one is not justified in inferring the intrinsic value of some non-human from any set of (...) observable properties, since that same set of properties could just as well exist in a world that lacks intrinsic value. However, since human beings do not have a faculty of intuition that would allow them to .. (shrink)

I focus on Fodor’s model of the relationship between special sciences and basic physics, and on a criticism of this model, that it implies that the causal stability of, e.g., the mental in its production of behaviour is nothing short of a miraculous coincidence. David Papineau and Graham Macdonaldendorse this criticism. But it is far less clear than they assume that Fodor’s picture indeed involves coincidences, which in any case their injection of a teleological supplement cannot explain. Papineau’s and Macdonald’s (...) problem is subtly different from a similar one presented by Adrian Cussins. This is no more effective against Fodor’s picture, but the kind of account of the relation between the physical and the psychological which could constitute a solution to Cussins’ problem is one which, for independent reasons, a physicalist of Fodor’s stripe ought to provide. (shrink)

This paper reconstructs Steel’s multiverse project in his ‘Gödel’s program’ (Steel [2014]), first by comparing it to those of Hamkins [2012] and Woodin [2011], then by detailed analysis what’s presented in Steel’s brief text. In particular, we reconstruct his notion of a ‘natural’ theory, describe his multiverse axioms and his translation function, and assess the resulting status of the Continuum Hypothesis. In the end, we reconceptualize the defect that Steel thinks CH might suffer from and isolate what it would take (...) to remove it while working within his framework. As our goal is to present as coherent and compelling a philosophical and mathematical story as we can, we allow ourselves to augment Steel’s story in places (e.g., in the treatment of Amalgamation) and to depart from it in others (e.g., the removal of ‘meaning’ from the account). The relevant mathematics is laid out in the appendices. (shrink)

Michael Smith has resisted Harry Frankfurt's claim that moral responsibility does not require the ability to have done otherwise. He does this by claiming that, in Frankfurt cases, the ability to do otherwise is indeed present, but is a disposition that has been `finked' or masked by other factors. We suggest that, while Smith's account appears to work for some classic Frankfurt cases, it does not work for all. In particular, Smith cannot explain cases, such as the Willing Addict, where (...) the Frankfurt devise - e.g. the addiction - is intrinsic to the agent. (shrink)

The paper considers the status of mathematics and mathematicians in German industrial labs from the 1920s. As an example, we take the use of statistical methods in the electrical engineering company Osram in Berlin. In the United States, the former employee and member of a special mathematical research department of the Bell Telephone Laboratories, Walter Andrew Shewhart (1891–1967), is regarded as the father of statistical quality control. Although the first textbook on applications of mathematical statistics to problems of mass production (...) was published in Germany in 1927, Germany was nevertheless generally considered as conservative in using statistical methods until 1945. In the past we have known little about whether and how these methods were actually applied in German industry before 1945. The present analysis is based on laboratory reports and other sources. It shows that in this field of research there was a close cooperation between industry and university, which was cut off in the mid 1930s due to the Nazi regime. Furthermore, we discovered that female researchers – such as Iris Runge (1888–1966) in the Osram company – could as individuals play a decisive role as mathematical consultants. The position of Runge will be described and compared with the position of mathematical researchers in other industrial labs. am Beispiel früher Anwendung von mathematischer Statistik in der Osram G.m.b.H.Hans Wußing zum 80. Geburtstag gewidmet. (shrink)

This is a review of Toby Handfield's book, "A Philosophical Guide to Chance", that discusses Handfield's Debunking Argument against realist accounts of chance.

Aesthetic Noise: The Philosophy of Intentional Listening considers the complex nature of noise within the framework of philosophical filtering, examining how, if noise is engaged with aesthetically, it can produce profound experiences and understandings. Applying the philosophies of Edmund Burke, Martin Heidegger, Jacque Derrida, and Julia Kristeva to works by Luigi Russolo, John Cage, Steve Reich, Alison Knowles, Annea Lockwood, Alyce Santoro, and Sunn O))), this book explores noise as an art material, and ultimately how it can become a (...) tool for activism and expanded creative possibilities. It demonstrates that, by engaging multiple philosophies in concert, the value of aesthetic noise is amplified, thus allowing the listener to better appreciate noise and its possibilities. Providing greater insights into noise as an aesthetic material, Aesthetic Noise will be of interest to researchers and students of sound studies, philosophy, and sound art, as well as sound designers, artists, musicians, and composers. (shrink)

central to virtually all contemporary thinking on self-consciousness and first-person authority. And a good measure of its importance has been not only as an evolving philosophical account of these phenomena, but also as a model of an account that places the capacity for specifically first-person awareness of one's mental states at the center of what it is to be a subject of mental states in the first place. For not every philosophical account of introspection will take its specifically first-person features (...) to be essential to it (e.g., if it is allowed that this "faculty" could in principle be directed at the mind of another person), or seek to account for the capacity for self-knowl-. (shrink)

The historical context of the philosophical work of St. Thomas Aquinas, by D. Knowles.--Form and existence, by P. Geach.--Categories, by H. McCabe.--Analogy as a rule of meaning for religious language, by J. F. Ross.--Nominalism, by P. Geach.--St. Thomas' doctrine of necessary being, by P. Brown.--The proof ex motu for the existence of God; logical analysis of St. Thomas' arguments, by J. Salamucha.--Infinite causal regression, by P. Brown.--St. Thomas Aquinas and the language of total dependence, by J. N. Deck.--Divine foreknowledge (...) and human freedom, by A. Kenny.--Intellect and imagination in Aquinas, by A. Kenny.--The immortality of the soul, by H. McCabe.--Aquinas on intentionality, by P. Sheehan.--The scholastic theory of moral law in the modern world, by A. Donagan.--The first principle of practical reason, by G. G. Grisez. (shrink)

Bobbio, N. Hacia una teoría funcional del derecho.--Bulygin, E. Sobre la regla de reconocimiento.--Gargaglione de Yaryura Tobías, E.L. El conocimiento y su validación.--Gómez, A.C. Acerca de la vinculación de la regla de reconocimiento con las restantes reglas secundarias.--Grün, E. y Farrel, M.D. Problemas de verificación en el derecho. Guibourg, R.A. La nulidad y su definición.--Klug, U. Consideraciones sobre las definiciones semánticas en derecho.--Miró Quesada, F. Sobre el derecho justo.--Nino, C.S. El concepto de validez y el problema del conflicto entre normas (...) de diferente jerarquía en la teoría pura del derecho.--Raggio, A.R. La refexión.--Ross, A. La finalidad del castigo.--Soler, S. La idea de "bien común."--Spolansky, N.E. El castigo del acto anterior al hecho prohibido.--Vernengo, R.J. Norma jurídica y esquema referencial.--Wright, G.H. von. Reencuentro con la lógica deóntica. (shrink)

Much of the sustained attention on pandemic preparedness has focused on the ethical justification for plans for the “crisis” phase of a surge when, despite augmentation efforts, the demand for life...

In lieu of an abstract, here is a brief excerpt of the content:April 3, 2010 (11:17 am) C:\Users\Milt\Desktop\backup copy of Ken's G\WPData\TYPE2902\russell 29,2 050 red.wpd 188 Reviews 1 A.yW. Brown, The Metaphysical Society (New York: Octagon, 1973), pp. 180–1. THE ETHICS OF BELIEF Sylvia Nickerson History & Philosophy of Science & Technology / U. of Toronto Toronto, on, Canada m5s 1k1 [email protected] Timothy J. Madigan. W.yK. CliVord and “The Ethics of Beliefz”. Newcastle, uk: CambridgeScholars Publishing, 2009. Pp. [x], 202. isbn (...) 1-84718-503-7. £29.99; us$44.99 (hb). The mathematician William Kingdon CliTord (1845–1879) is generally remembered as a potentially great man whose life was cut short before his genius was fully realized. During his lifetime CliTord was well known in London as a public intellectual and noted authority on science. He was also an iconoclast, a leader in the application of Darwinian principles to areas beyond biology, and a proponent of non-Euclidean geometry. Unlike other agnostics, CliTord did not mourn the loss of his religious belief, nor did he worry that a secularized society would bring about general social decay. While other scientiWc naturalists worried that a collapse of religion would destroy morality and lead to social disintegration, CliTord willingly ceded the universal truths religion oTered, embracing the uncertainty that scientiWc knowledge actually entailed. He even dared to call himself an atheist. However, CliTord’s death at age 34 curtailed the trace of his thought. What remains is consigned to his scant private notebooks and collected works. Perhaps it was the brevity of his life that has led to his neglect within the history of science; no comprehensive appraisal of his mathematical work has been written. CliTord’sbest-knownnon-mathematical statementisthat“itiswrongalways, everywhere, and for anyone, to believe anything upon insuUcient evidence.” This was the statement he defended in his lecture “The Ethics of Beliefz”, which he delivered to London’s Metaphysical Society in 1876. The Metaphysical Society, founded in 1869 to promote discussion between religious believers and scientiWc rationalists, ceased operation in 1880 after members could not Wnd enough common ground to begin debate. The rationalist position CliTord argues in “The Ethics of Beliefz” stands on the far side of the spectrum within this discourse. CliTord’s immoderate stance, along with his use of biblical rhetoric to argue a secularist position, was calculated to provoke conservative intellectuals and institutions.1 When his essay appeared in the January 1877 issue April 3, 2010 (11:17 am) C:\Users\Milt\Desktop\backup copy of Ken's G\WPData\TYPE2902\russell 29,2 050 red.wpd Reviews 189 of Contemporary Review, it proved antagonistic enough that it led in part to the dismissal of James Knowles as editor. Timothy Madigan’s book W.yK. CliVord and “The Ethics of Beliefz”z provides an introduction to and analysis of CliTord’s ethical philosophy. His goal is to outline the historical context from which CliTord’s most famous essay arose, and to analyze the merits and demerits of its argument through the viewpoints of critics and freethinkers from the nineteenth century to the present. Madigan gives a brief history of the Victorian crisis of faith, CliTord’s mathematical work, and the biographical details of his life. He presents the argument CliTord makes within “The Ethics of Beliefz”, and outlines the critical response from his contemporaries, including founding members of the Metaphysical Society William George Ward and Richard H. Hutton, poet Matthew Arnold, physiologist George John Romanes, and American psychologist and philosopher William James. Madigan also discusses the positions argued by other rationalists in the 1870s,1880sandlater(Leslie Stephen, Karl Pearson, FriedrichNietzsche, Charles Peirce and Bertrand Russell) and by modern philosophers who have contributed to the rationalist/religionist debate (C.yS. Lewis, J.yL. Mackie, Michael Martin, Peter van Inwagen, Susan Haack, Anthony Quinton, and Lorraine Code). In Chapter 6 Madigan presents his own defence of CliTord’s ethics of belief. While early sections of the book provide a helpful summary of previously published work, I found Madigan’s discussion of CliTord’s writings on psychology and theory of mind particularly valuable (pp. 58–65). Madigan notes positively that CliTord’s contribution helped steer the early development... (shrink)

Large Language Models (LLMs) could be a useful tool for lawyers. However, empirical research on their effectiveness in conducting legal tasks is scant. We study securities cases involving cryptocurrencies as one of numerous contexts where AI could support the legal process, studying GPT-3.5’s legal reasoning and ChatGPT’s legal drafting capabilities. We examine whether a) GPT-3.5 can accurately determine which laws are potentially being violated from a fact pattern, and b) whether there is a difference in juror decision-making based on complaints (...) written by a lawyer compared to ChatGPT. We feed fact patterns from real-life cases to GPT-3.5 and evaluate its ability to determine correct potential violations from the scenario and exclude spurious violations. Second, we had mock jurors assess complaints written by ChatGPT and lawyers. GPT-3.5’s legal reasoning skills proved weak, though we expect improvement in future models, particularly given the violations it suggested tended to be correct (it merely missed additional, correct violations). ChatGPT performed better at legal drafting, and jurors’ decisions were not statistically significantly associated with the author of the document upon which they based their decisions. Because GPT-3.5 cannot satisfactorily conduct legal reasoning tasks, it would be unlikely to be able to help lawyers in a meaningful way at this stage. However, ChatGPT’s drafting skills (though, perhaps, still inferior to lawyers) could assist lawyers in providing legal services. Our research is the first to systematically study an LLM’s legal drafting and reasoning capabilities in litigation, as well as in securities law and cryptocurrency-related misconduct. (shrink)

Fabvla misere mutila: this notice in the Oxford edition, reinforced in the critical apparatus, warns the reader against the transmitted text of the Heradidae. It tends to perpetuate the view which Wilamowitz, following up the hints of G. Hermann and A. Kirchhoff, propounded in 1882. The sweeping assurance of his famous article gave it a publicity which makes a detailed rehearsal superfluous. Wilamowitz throughout his life stuck to the opinion that ‘wir lesen die Herakliden in der Bearbeitung eines Regisseurs’. Dissentient (...) voices have been raised from time to time. M. Pohlenz in 1930 even proposed an interpretation of the Heradidae which quietly discarded the thesis of Wilamowitz. Nevertheless the latter appears still to hold the field at least in the English-speaking countries. If it is correct, the Heradidae of Euripides is beyond our reach. This conclusion has indeed, quite recently, been drawn by H. D. F. Kitto. (shrink)

La noticia de la inauguración en mayo de este año del Global Hub for Pandemic and Epidemic Intelligence en Berlín pasó un tanto desapercibida. Esta fue una de las últimas jugadas maestras de estrategia política de la fulgurante carrera ciertamente no académica de la canciller alemana Angela Merkel, quien anunció que Alemania aportará una financiación anual de treinta millones de euros.